Toxic Exposure Data and Research Sources
Please use the links below to view toxic exposure research and toxic exposure related data collection efforts that are being carried out by various Federal Government agencies, institutions, and organizations.
Chemical and Biological Exposures
Utilize this webpage to find information on the Department of Defense's (DoD) overview of chemical and biological exposures. For additional information on chemical and biological exposures, please visit the DoD websites listed below:
ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. Explore over 450,000 research studies in all 50 states and in over 200 countries. You may use this site to explore research studies related to toxic exposure, searching by condition or disease, intervention or treatment, or location.
Comprehensive Epidemiologic Data Resource
Comprehensive Epidemiologic Data Resource (CEDR) is the U.S. Department of Energy (DOE) electronic database comprised of health studies of DOE contract workers and environmental studies of areas surrounding DOE facilities. CEDR provides independent researchers and educators with access to de-identified data collected since the Department’s early production years. Current CEDR holding including more than 80 studies of over 1.5 million workers at 34 DOE sites.
Most of CEDR’s holdings are derived from epidemiologic studies of DOE workers at many large nuclear weapons plants, such as Hanford, Los Alamos, the Oak Ridge reservation, Savannah River Site, and Rocky Flats. These studies have primarily used death certificate information to identify excess deaths and patterns of disease among workers to determine what factors contribute to the risk of developing cancer and other illnesses. In addition, many of these studies have radiation exposure measurements on individual workers.
CompTox Chemicals Dashboard
The Environmental Protection Agency's (EPA) CompTox Chemicals Dashboard serves as a resource for providing public access to chemistry, exposure and toxicity data for over 1.2 million chemicals.
Congressionally Directed Medical Research Programs
DoD's Congressionally Directed Medical Research Programs originated in 1992 via a Congressional appropriation to foster novel approaches to biomedical research in response to the needs of its stakeholders-the American public, the military, and Congress. Please use this site to explore research programs, such as those related to Gulf War Illness, military burn, or toxic exposures. You may also use this site to search for awards and publications related to toxic exposure research programs.
This page is designed to provide service members, Veterans, their families and the public with information on what happened during chemical and biological (CB) testing conducted years ago that potentially affected the health of those who served. It provides information on the tests conducted by DoD that possibly resulted in CB exposures only.
Environmental Impact Review at the Center for Drug Evaluation and Research
The Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) performs an essential public health task by making sure that safe and effective drugs are available to improve the health of people in the United States.
The National Environmental Policy Act of 1969 (NEPA) requires all Federal agencies to assess the environmental impact of their actions and to ensure that the interested and affected public is informed of the environmental analyses. FDA considers the environmental impacts of its actions as an integral part of its regulatory process. FDA regulations at 21 CFR Part 25 (“Environmental Impact Considerations”) specify that environmental assessments (EAs) must be submitted as part of certain new drug applications (NDAs), abbreviated new drug applications (ANDAs), applications for marketing approval for biological product, supplements to such applications, investigational new drug applications (INDs) and for various other actions, unless the action qualifies for a categorical exclusion. Learn more about the Environmental Impact Review at CDER.
FDA - Environmental Studies
Learn about FDA's Environmental Studies.
Guidance for Industry – Environmental Assessment of Human Drug and Biologics Applications
This guidance, produced by the FDA’s CDER and Center for Biologics Evaluation and Research (CBER), provides information on when an environmental assessment (EA) should be submitted; it also makes recommendations on how to prepare EAs for submission of drug or biologics applications to the CDER and CBER.
Gulf War and Health, Volume 11: Generational Health Effects of Serving in the Gulf War
In response to health concerns of Gulf War veterans, Congress in 1998 directed VA to contract with the National Academies of Science, Engineering, and Medicine to evaluate the scientific and medical literature regarding associations between illness and exposure to the toxic agents, environmental and wartime hazards, and preventative medicines and vaccines associated with Gulf War service. Read the report.
Utilize this database to find approximately 512,000 bibliographic reference and over 130,000 with attached full-text, including information declassified in response to Freedom of Information Act requests. In addition to these documents, OpenNet references older document collections from several DOE sources. This database is updated regularly as more information becomes available.
Safer Chemicals Research Products in the Science Inventory
Utilize this public facing repository to access EPA scientific publications related to safer chemicals research.
EPA’s Safer Chemicals Research program is transforming chemical risk-based decisions by conducting high-quality, innovative scientific research.
Utilize this website to find information on EPA’s Chemical Safety for Sustainability Research Program, including finding additional information on EPA’s work in:
Site Exposure Matrices
Department of Labor’s (DOL) database is used to organize exposure data for all facilities covered under Part E of the Energy Employees Occupational Illness Compensation Program Act (EEOICPA).
Utilize this repository to find information on toxic substances present at DOE and Radiation Exposure Compensation Act (RECA) facilities covered under Part E of EEOICPA. This website also contains information regarding scientifically established links between toxic substances and recognized occupational illnesses.
U.S. Army Research Institute of Environmental Medicine
U.S. Army Research Institute of Environmental Medicine (USARIEM) is internationally recognized as the DOD’s premier laboratory for Warfighter health and performance research and focuses on environmental medicine, physiology, physical and cognitive performance, and nutrition research.
VA Epidemiology Research Studies
Epidemiology is the study of health in populations to understand the causes and patterns of health and illness. The Epidemiology Program a research division of VA’s Health Outcomes Military Exposures, conducts epidemiology research studies and surveillance (the collection and analysis of data) on the health of Veterans.
Utilize this repository to view research studies and surveillance on Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans, Gulf-Era Twin Registry Veterans, Gulf War Era Veterans with 1990-1991 service, Vietnam Era Veterans, and Project 112/SHAD Veterans.
VA Funded Research Projects
Use this repository to search for research projects funded by VA's Office of Research and Development. Research projects are available for Fiscal Year 2023 – FY 2017.
War Related Illness and Injury Study Center
The War Related Illness and Injury Study Center (WRIISC) research program focuses on improving the health of Veterans with post deployment health concerns. WRIISC researchers and clinicians work together to identify new problems in returning Veterans and respond to their health concerns. We use the knowledge generated by our research to identify promising treatments and the most current evidence-based care for our Veterans.
WRIISC research interests cover a wide range of topics including environmental exposures and post deployment health, long-term health effects of combat, memory and food difficulties, traumatic brain injuries, neurological diseases, integrative health and wellness approaches, disabilities resulting from deployment illnesses or injuries, women Veterans’ health, and risk communication of deployment related concerns.